|
DERMOID SINUS
IN THE RHODESIAN RIDGEBACK
(A Review by a Veterinarian)
Taken from South African Rhodesian Ridgeback Club, Ridgeback Review
THE FORMATION AND SIGNIFICANCE OF DERMOID SINUS
The Rhodesian Ridgeback is a modern breed of dog that originated in the late nineteenth century, by
the crossing of indigenous Hottentot dogs with various European breeds introduced into the Cape by the early settlers.
The breed standard was established with the formation of the Rhodesian Ridgeback Club of Bulawayo in
1922. The main characteristics of the breed is, as its name implies-a ridged back, which is formed in the haircoat along
the top midline of the dog's back. The ridge is formed by hair, which grows in the opposite direction to the hair of
the surrounding coat.
Breeders of Ridgebacks are aware of a well-known defect which occurs in the breed, the Ridgeback "Cyst"
or as it is more correctly named in the scientific terminology, the Dermoid Sinus. (Dermoid-arising from the skin, Sinus-a
cavity or channel).
Dermoid Sinuses are narrow tube-like structures, which are derived from a skin defect. They penetrate
from the skin surface to varying depths downward into the muscles and towards the spinal cord. They are situated in
the midline of the neck and croup, which is in front and behind the area occupied by the ridge (Fig 1).
| Fig 1: Areas marked "X" indicate the sites at |
|
| which dermoid sinuses may develop |
This is the only known congenital defect that occurs in the breed. (Congenital means that the
defect is formed before birth). When considered as a defect in the dog family as a whole, Dermoid Sinuses occur only
very rarely in dogs, other than Ridgebacks or Crossbred Ridgebacks. It must therefore be obvious that it is an inherited
defect which has become widespread in the "blood lines" of the breed as a result of the early selective breeding of the original
stock from which the Ridgebacks of today have been produced.
The incidence of the defect throughout the breed is not known, as the recording of the numbers of
Dermoid Sinus affected pups in litters has not been done on a scale large enough to enable a statistical analysis to be carried
out. In fact, the occurrence of Dermoid Sinus affected pups on the litters of breeders has been kept confidential, as
most breeders feel that there is considerable stigma attached to dogs and bitches amongst whose offspring Dermoid Sinus affected
puppies occur.
At this point I would like to state that with the present situation of breeding with selected outstanding
dogs and bitches, no breeder without a program of progeny testing can be sure that his "blood lines" is free from the hereditary
Dermoid Sinus. (The hereditary aspects of the condition will be dealt with in part two of this article). Thus,
every purchased Ridgeback may be considered a potential carrier of the condition.
THE FORMATION OF DERMOID SINUS
To understand the way, in which a Dermoid Sinus is formed, it is necessary to have some idea of how
the embryo develops from a single fertilized egg cell in the womb of the bitch. Dermoid Sinus is a congenital defect
that arises from a defect in the development of the embryo of a puppy.
A fertilized egg resulting from a successful mating is a single simple cell. From this cell
a puppy consisting of millions of specilized cells, which constitute the tissues and organs, must me formed in 63 days.
| Fig 2: Early stages of cell division. |
|
A: Single cell of fertilized egg
B: 2 cell stage.
C: 4 cell stage.
D: 8 cell stage.
E: Multi-celled Spherical Mass, many cell divisions later.
This process is accomplished by a rapid increase in the number of cell division. The fertilized
egg (a single cell) divides into two cells and subsequent divisions each double the previous number of cells, so that the
numbers very rapidly increase. In the ten successive divisions, 1042 cells are produced, and it can be seen that, by
this means, the total number of cells is soon very large.
The next stage is the organisation of the mass of cells produced to form a puppy. The organisation
process, which takes place for about the first three weeks of pregnancy, is called the embryonic development. When the
embryo is fully developed, a complete miniature puppy is formed which now becomes known as a foetus. The next six weeks
of pregnancy only results in the increase in size of the foetus to its normal birth size.
Dermoid Sinuses arise from a defect in the development of the embryo. Cell division gives rise
to a spherical mass of cells. The outer layer of these cells will eventually become the skin of the puppy. Another
part of the body also develops from this outer layer of cells. This is the brain and the spinal cord, which runs from
the head to the base of the tail. The problem now is -how does the outer layer of cells give rise to the brain and the
spinal cord?
This is accomplished by the formation of a long groove over half the surface of the spherical mass
of cells. The groove deepens and then its outer edges close together giving rise to a tube-like structure. This
tube-like structure which is later to become the brain and spinal cord, sinks deeper below the surface layer and becomes detatched
from it. This process is shown in Figure 3.
| Fig 3: Schematic Formation of Brain & Spinal Cord |
|
A: Formation of groove on surface of sphere of cells as seen from above groove.
B: Section through X-Y to show outer layer of cells folding inwards.
C: Deepening of the fold.
| Fig 3: Continued |
|
A: Closing over of edges of the groove.
B: Closed.
C: Separation of outer layer (skin) from tubular structure (spinal cord).
Dermoid Sinuses occur when small areas of attachment between the outer layer of cells (the skin)
and the tubular structure (later to become the brain and the spinal cord) remain.
In the puppy, this defective separation of the embryological tissues is present as a thin tubular
attachment extending from the skin of the midline of the top surface of the dog to the deeper tissues below, and as deep as
the spinal cord in some cases.
The depth to which this tubular skin defect penetrates is the criterion used for the classification
of four types of Dermoid Sinuses, shown in Figure 4 below.
| Fig 4: Cross section through a dog's neck |
|
| TYPES OF DERMOID SINUSES |
TYPE I: Penetrates below the skin surface, its fatty tissue
overlying the neck muscles.
TYPE II: Penetrates into the muscles of the neck.
TYPE III: Penetrates to the supraspinous ligament, which runs over the top of the
vertebrae.
TYPE IV: Penetrates to the spinal cord between the vertebrae.
THE SIGNIFICANCE OF DERMOID SINUS
The detrimental effects of Dermoid Sinus are not just concerned with the fact that a visible anatomical
defect is apparent in affected animals, but rather the complications which can arise as a result of a Dermoid Sinus becoming
infected with bacteria.
The narrow tube of skin which descends below the skin surface is lined with all the normal skin structures
and of special significance are: hair; sweat; and oil glands.
The thin central cavity, which runs down the Dermoid Sinus, becomes filled in time with hair, skin
oil and skin scales. The contents usually become an ideal medium where bacteria, which are normally present on the skin,
may grow. They gain access to the material through the small pore-like opening at the point of attachment of the Dermoid
Sinus on the skin surface.
The accumulated skin secretion undergoes a process of putrefaction and the skin barrier of the Sinus
walls breaks down and bacteria invade the tissues deep below the skin surface. This usually results in the formation
of an abscess, which eventually ruptures to the outside and drains as a chronically discharging purulent wound.
Extensive surgical and medical treatment may be necessary to clear up such a complication and in
some cases septic dermoid sinus may be unresponsive to treatment.
If a Dermoid Sinus is recognized in a dog before it becomes septic, it can be removed surgically,
with a good chance that no further complications will occurr. In most cases, however, owners of animals are not aware
of the presence of Dermoid Sinus and shortly thereafter septics almost always sets in. Subsequently, the owners are
obliged to obtain veterinary treatment to resolve the distressing complications. This may be costly to the dog owner
and embarrassing to the breeder when it is pointed out that he has sold a dog with a latent defect.
DIAGNOSIS OF DERMOID SINUS
In the puppy, Dermoid Sinus can be detected by raising the skin in a longitudinal fold along the
top midline in the area in which Dermoid Sinuses are known to occur (i.e. in front of and behind the ridge). If the
skin fold is raised with one hand and the skin allowed to slip back and forward between the thumb and forefinger of the other
hand the presence of the Sinus can be felt as a thin cord-like structure between the two layers of skin (Fig 5 below).
| Fig 5: Diagnosis of Dermoid Sinus |
|
Feeling for presence of Dermoid Sinus by sliding longitudinal fold of skin between the index
finger and thumb.
Raising the skin fold in this way tenses the tissues and a Dermoid Sinus will be pulled tautly between
its skin attachment in the top midline and its attachment in the muscles below.
The diagnosis can be confirmed by shaving the hair from the skin over the point at which the Dermoid
Sinus is attached. A small pore like opening in the skin from which a small tuft of hair protrudes is usually seen.
This is the opening of the Dermoid Sinus on the skin surface.
The older the puppy, the thicker the Sinus will be and more easily it may be recognized.
It must be realized, however, that the recognition of a Dermoid Sinus in puppies may not always be
as easy a procedure as the above description may suggest. If it is missed, a Dermoid Sinus may lie dormant for years
before it comes to the notice of an owner by becoming septic. If in doubt, the professional assistance of a Veterinarian
should be obtained.
|
